MCAT Style Quiz Question 14.3

A deficiency in the glycolytic enzyme phosphoglycerate mutase, which converts 3-phosphoglycerate to 2-phosphoglycerate, led to rapid muscle fatigue in a patient who was being tested with a treadmill stress test. (a) What is the explanation for this observation? (b) Would you be able to measure high lactate levels in muscle after the test? Explain.

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