MCAT Style Quiz Question 6.1

Binding of the negatively charge allosteric effector 2,3-bisphosphoglycerate (2,3-BPG) stabilizes the T state of hemoglobin.  A lysine residue in the central cavity of hemoglobin interacts with 2,3-BPG.  In a hemoglobin variant, there is a substitution of this lysine by an asparagine.  Relative to the wild-type hemoglobin, this variant would be expected to have _____________________.