Glycoconjugates and ABO Blood Types

Professor Miesfeld at the University of Arizona

This Online Biochemistry Course is based on Miesfeld’s Biochemistry (3rd Edition)

Miesfeld BIOC 385 Module 2 Topic 6 – Glycoconjugates and ABO Blood Types

Bioc385-B3e_M02.T06-Glycoconjugates.RLM Download

Glycoconjugates are glycoproteins and glycolipids that drive cell adhesion, immune recognition, and the ABO blood group system. This video covers N-linked and O-linked glycosylation and shows how a few amino acid differences between the GTA and GTB enzymes set A, B, AB, or O blood type and transfusion compatibility.

Key concepts covered: glycoconjugates, lectin-glycan recognition, N-linked and O-linked glycosylation, glycosyltransferases, ABO blood groups, GTA and GTB enzymes, codominant inheritance, universal donors, transfusion compatibility.