Professor Miesfeld at the University of Arizona
This Online Biochemistry Course is based on Miesfeld’s Biochemistry (3rd Edition)
Fatty acids are activated, carried into mitochondria by the carnitine cycle, and broken down by beta-oxidation into acetyl-CoA, NADH, and FADH2 to make ATP during fasting and exercise. This video works through the energy yield of palmitate oxidation and connects fatty acid breakdown to the citrate cycle and ketogenesis.
Key concepts covered: fatty acid activation (fatty acyl-CoA synthetase), carnitine transport cycle (CPT I/II), four reactions of beta-oxidation, acetyl-CoA, palmitate ATP yield (106 net ATP), malonyl-CoA control, metabolic water, hypoglycin A toxicity.
Everyday BioChem 