Tag Archives: Miesfeld

Signaling activity of G proteins is controlled by GTPase activating proteins (GAPs) and Guanine exchange factors (GEFs). What are the mechanisms by which GAPs and GEFs control G protein functions?

A deficiency in the glycolytic enzyme phosphoglycerate mutase, which converts 3-phosphoglycerate to 2-phosphoglycerate, led to rapid muscle fatigue in a patient who was being tested with a treadmill stress test. (a) What is the explanation for this observation? (b) Would you be able to measure high lactate levels in muscle after the test? Explain.

Below is a fractional saturation curve for O2 binding to adult hemoglobin. Assume that curve Y represents a condition at pH 7.4 and with a normal physiological level of 2,3-BPG. Curve X represents a condition that __________________.

In most enzymes, the required active site amino acids consists of only a few residues. Why is the rest of the protein necessary for full enzyme function?

Below is a schematic representation of a dimerized receptor tyrosine kinase. Where is the kinase function located?

Which hormone decreases the rate of glycolytic flux, while at the same time, stimulates flux through the gluconeogenic pathway; under what condition is this likely to occur?

Raffinose-series oligosaccharides are hard for humans to digest because____________.

What is the mechanism by which methicillin kills penicillin-resistant bacteria?

Why are A-T rich regions more susceptible to DNA denaturation than G-C rich regions?

Ovalbumin is the major protein constituent of egg white. What is the primary folded state of ovalbumin protein in a fully cooked egg?

Which molecular event is most responsible for transducing the signal from outside of the cell to the inside of the cell?

A hydrogen bond can best be described as a ________________.