Category Archives: Miesfeld Biochemistry

A reduction in the catalytic activity of carbonic anhydrase would lead to __________ efficient oxygen delivery to tissues by hemoglobin as a result of a(n) __________ Bohr effect.

Albinism is characterized by white skin due to a defect in the enzyme arginase (1) tyrosinase (2), which leads to a block in the pathway needed to synthesize adrenaline (3) / melanin (4).  Animals with this condition have a(n) increased (5) / decreased (6) risk of skin cancer. The genetic disease phenylketonuria is caused byContinue reading “MCAT Style Quiz Question 14.1”

Signaling activity of G proteins is controlled by GTPase activating proteins (GAPs) and Guanine exchange factors (GEFs). What are the mechanisms by which GAPs and GEFs control G protein functions?

A deficiency in the glycolytic enzyme phosphoglycerate mutase, which converts 3-phosphoglycerate to 2-phosphoglycerate, led to rapid muscle fatigue in a patient who was being tested with a treadmill stress test. (a) What is the explanation for this observation? (b) Would you be able to measure high lactate levels in muscle after the test? Explain.

Below is a fractional saturation curve for O2 binding to adult hemoglobin. Assume that curve Y represents a condition at pH 7.4 and with a normal physiological level of 2,3-BPG. Curve X represents a condition that __________________.

In most enzymes, the required active site amino acids consists of only a few residues. Why is the rest of the protein necessary for full enzyme function?

Below is a schematic representation of a dimerized receptor tyrosine kinase. Where is the kinase function located?